Single-cell pluripotency regulatory networks
نویسندگان
چکیده
منابع مشابه
Single-cell pluripotency regulatory networks.
Pluripotent stem cells (PSCs) are a popular model system for investigating development, tissue regeneration, and repair. Although much is known about the molecular mechanisms that regulate the balance between self-renewal and lineage commitment in PSCs, the spatiotemporal integration of responsive signaling pathways with core transcriptional regulatory networks are complex and only partially un...
متن کاملDecipher Plant Gene Regulatory Networks Using Single Plant Cell Types
Gene expression is under the control of transcription factors and various epigenomic modifications of the chromatin such as the methylation patterns of the genomic DNA (gDNA) and various chemical changes of histone proteins. Small RNAs are another important regulator of plant chromatin structure and gene expression [1,2]. The integration of different epigenomic marks (i.e. gDNA methylome, histo...
متن کاملChromatin regulatory mechanisms in pluripotency.
Stem cells of all types are characterized by a stable, heritable state permissive of multiple developmental pathways. The past five years have seen remarkable advances in understanding these heritable states and the ways that they are initiated or terminated. Transcription factors that bind directly to DNA and have sufficiency roles have been most easy to investigate and, perhaps for this reaso...
متن کاملMapping the networks for pluripotency.
There has been an immense interest in embryonic stem cells owing to their pluripotent property, which refers to the ability to differentiate into all cell types of an embryo. In the maintenance of this pluripotent nature, transcription factors play essential roles, and signalling pathways also act to sustain the undifferentiated state. Recent studies have unravelled multiple forms of interconne...
متن کاملA model for genetic and epigenetic regulatory networks identifies rare for transcription factor induced pluripotency
With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells for patient-specific regenerative medicine. We have developed a computational model for the arch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2016
ISSN: 1615-9853
DOI: 10.1002/pmic.201500528